Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 In one trial, administration of an aged garlic extract reduced the number of infections and relieved diarrhea (page 163) in a group of patients with AIDS.77 Garlic's active constituents have also been shown to kill HIV in the test tube, though these results have not been confirmed in human trials.78
A preliminary trial of isolated andrographolides, found in andrographis (page 626), determined that while they decreased viral load and increased CD4 lymphocyte levels in people with HIV infection, they also caused potentially serious liver problems and changes in taste in many of the participants. |
C. P. Khare
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 In health-food stores liquid or capsules of Kyolic aged garlic extract, Kyolic EPA (a combination of aged garlic extract and fish oil) are available in the United States.
Oil-based garlic preparations are questionable, since allicin is unstable in oil.
According to Tyler, dried garlic preparations are most effective if they are enteric coated. This will allow them to pass intact through the stomach to the small intestine where the enzyme can act under the alkaline conditions present there. |
Michael T. Murray
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 The same can be said for aged garlic and garlic oil products, as these forms of garlic contain absolutely no allicin or allicin-degradation products.
There are a couple of vital considerations when choosing a garlic product. First of all, it is important to make sure that the product provides a sufficient level of allicin. Since allicin is not actually in the product at any significant levels, manufacturers often refer to the allicin potential or allicin yield. These terms signify the amount of allicin produced when alli-inase is activated in the garlic tablet or powder. |
C. P. Khare
See book keywords and concepts |
| In health-food stores liquid or capsules of Kyolic aged garlic extract, Kyolic EPA (a combination of aged garlic extract and fish oil) are available in the United States.
Oil-based garlic preparations are questionable, since allicin is unstable in oil.
According to Tyler, dried garlic preparations are most effective if they are enteric coated. This will allow them to pass intact through the stomach to the small intestine where the enzyme can act under the alkaline conditions present there. |
Amarjit S. Basra
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 Pretreatment with aged garlic extract (1-4 pg-mLr1) also protected cultured pulmonary vascular endothelial cells from subsequent oxidative injury induced by hydrogen peroxide, and inhibits Cu2+ induced oxidative modification of low-density lipoproteins in vitro.94 Using molecular biology techniques, the expression of several genes, including FR alpha, calcyclin, and nexon, has been shown to be up-regulated in human gastric cancer cells, following treatment with allitride garlic extract. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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| In a preliminary study, supplementation with a special aged garlic extract (Kastamonu Garlic) in the amount of 1 ml per 2.2 pounds of body weight per day for one month resulted in a 32% reduction in the size of the prostate gland and a significant improvement in urinary symptoms.22 It is not known whether other forms of garlic would have the same effect.
Pygeum (page 734), an extract from the bark of the African tree, has been approved in Germany, France, and Italy as a remedy for BPH. |
Hyla Cass
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 Grapeseed extract: 100-200 mg daily
?Hawthorn: 1,500 mg daily
?Magnesium: 500-600 mg daily
Note: While antioxidant supplements, like most nutrients, almost never interact with drugs, some herbs with drug-like effects can have risky interactions with prescription medications.
You can often lower your cholesterol and blood pressure with diet, lifestyle, and natural supplements. Then, when medications are necessary, use them with caution, take the lowest dose possible, and make sure to take your supplements to stave off depletion and enjoy the best possible heart health. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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| Aged garlic products lack allicin, but may have activity due to the presence of S-allylcysteine.
Many publications have shown that garlic supports the cardiovascular system. While earlier trials suggest it may mildly lower cholesterol (page 223) and triglyceride (page 235) levels in the blood,2,3'4 more recent trials found garlic to have minimal success in lowering cholesterol and triglycerides.5, 6'7 Garlic also inhibits platelet stickiness (aggregation) and increases fibrinolysis,8 which results in a slowing of blood coagulation. |
| Aged garlic extract, but not raw garlic, has been shown, to prevent oxidation of LDL cholesterol in humans,97 an event believed to be a significant factot in the development of atherosclerosis.
Ginkgo (page 681) may reduce the risk of atherosclerosis by interfering with a chemical the body sometimes makes in excess, called platelet activating factor (PAF).98 PAF stimulates platelets to stick together too much; ginkgo stops this from happening. Ginkgo also increases blood circulation to the brain, arms, and legs.99
Garlic and ginkgo also decrease excessive blood coagulation. |
| In most but not all trials, aged garlic extracts and garlic oil (both containing no allicin) have not lowered cholesterol levels in humans.315, 316 Therefore, neither of these supplements can be recommended at this time for cholesterol lowering. Odor-controlled, enteric-coated tablets standardized for allicin content are available and, in some trials, appear more promising.317 Doctors typically recommend 900 mg per day (providing 5,000 to 6,000 meg of allicin), divided into two or three admininstrations. |
James F. Balch, M.D.
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 It might be added that the credibility that garlic has enjoyed is in large degree due to the result of well over one hundred scientific studies that have been conducted on aged garlic extract and its constituents, not on allicin. The constituents that are unique to aged garlic extract include S-allymercaptocysteine and others. Those who insist that allicin is the key to garlic's potency will also insist that garlic should be eaten raw or lightly cooked. However, one researcher, Dr. |
Mark Blumenthal
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 Garlic oil is not present in fresh or dried garlic bulbs; instead, the oil is produced by converting water-soluble thiosulfinates to oil-soluble sulfides via steam distillation. aged garlic involves long-term extraction in dilute ethanol for up to 20 months, then drying; pickling garlic involves immersion in vinegar (5% acetic acid) (Amagase et al, 2001; Lawson, 1998a).
Primary Uses Cardiovascular
• Hyperlipidemia (Isaacsohn et al, 1998; Lash et al, 1998; McCrindle etal, 1998; Steiner ^/. |
| However, a clinical trial on a proprietary aged garlic extract (AGE) showed no prolonged bleeding in patients taking warfarin. Reports of increased clotting time suggest that patients avoid garlic at least one week prior to surgery. pregnancy and lactation: There are no restrictions on using garlic during pregnancy and lactation. A controlled trial showed that garlics major sulfur-containing volatile compounds are transmitted to human milk, leading to infants' improved drinking habits.
Adverse Effects
Garlic odor may permeate the breath and skin. |
| Anti-allergic effects of aged garlic extract. Phytomedicine 1997;4(4):335-40.
Lamm DL, Riggs DR. The potential applications of Allium sativum (garlic) for the treatment of bladder cancer. Urol Clin North Am 2000;27(1): 157-62.
Lash JP, Cardoso LR, Mesler PM, Walczak DA, Pollak R. The effect of garlic on hypercholesterolemia in renal transplant patients. Transplant Proc 1998;30(1):189-91.
Lau BHS. Suppression of LDL oxidation by garlic. / Nutr 2001; 131 Suppl 3:985S-8S.
Lau BHS. Detoxifying, radioprotective and phagocyte-enhancing effects of garlic.
Internat Clin Nutr Rev 1989;9(1):27-31. |
Walter Last
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 Also useful are vitamin B-complex, calcium orotate, magnesium, selenium, zinc, coenzyme Q10, L-glutamine, L-lysine, aged garlic, freeze-dried liver, propolis, echinacea, maca, and either L-cysteine and L-methionine or MSM. Initially try weekly vitamin B12 injections or daily vitamin B12 tablets dissolved under the tongue. additional therapies: Try Candida treatment, herbal parasite cure, electronic blood purifier, magnetic pulser, colloidal silver, and copper salicylate. Minimize electro-stress and sanitize the teeth (see step 8). |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
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| A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and conconavalin. Proc Ann Meet Am Assoc Cancer 1993; 34: A3297
22. Lau BH, Yamasaki T, Gridley DS. garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother 1991;
3: 103-107,
23. Kandil OM et al. Garlic and the immune system in humans. Its effect on natural killer cells. Fed Proc 1987; 46: 441
24. Hirao Y et al. Activation of immunoresponder cells by the protein fraction from aged garlic extract. Phytotherapy Res 1987;
1: 161-164
25. |
Dr. Gary Null
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 Animal research showing that aged garlic extract improves memory acquisition suggests that the extract may be useful for humans.
T. Moriguchi et al., "Prolongation of Life Span and Improved Learning in the Senescence Accelerated Mouse Produced by aged garlic Extract," Biol. Pharm. Bull. 17, no. 12 (December 1994): 1589-94.
A study of 71 subjects over 60 years of age showed that treatment with American ginseng prolonged functional age. Effectiveness for the treated group was about 90 percent.
J. Cui and K. J. |
| Animal research showing that aged garlic extract improves memory acquisition suggests that the extract may be useful for humans.
T. Moriguchi et at, "Prolongation of Life Span and Improved Learning in the Senescence Accelerated Mouse Produced by aged garlic Extract," Biol. Pharm. Bull. 17, no. 12 (December 1994): 1589-94.
A study of 71 subjects over 60 years of age showed that treatment with American ginseng prolonged functional age. Effectiveness for the treated group was about 90 percent.
J. Cui and K. J. |
Dr. John Heinerman
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 Therefore, I recommend that aged garlic extract from Japan be given instead: one-half teaspoon of the liquid twice daily or two capsules of the aged garlic-chromium formula opened and their contents mixed in with every meal. (See Product Appendix under Wakunga.)
Two other herbs I have used a lot in animal and human diabetes cases are kelp and dandelion root. Generally, the encapsulated powders work better for this type of problem than a tea or liquid might. I always use them together, never alone. For every two capsules of dandelion root, I include one tablet or capsule of kelp. |
Phyllis A. Balch, CNC
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 Liquid Kyolic, which is an odorless aged garlic extract produced by Wakunaga of America Company, can be added to fresh juices. You can also use it in retention enemas. (More about that subject later in this chapter.)
Why the Emphasis on Quality Water?
Continual hydrating and rehydrating of the body is very important. If the body becomes dehydrated, it is thrown into "crisis mode" and many vital functions shut down or cease to work effectively. For this reason, it is important to select the best sources of water available and drink at least eight glasses a day. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
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 To highlight the superiority of fresh garlic preparations over aged garlic, let's examine the results of the effects of both on blood pressure and cholesterol and triglyceride levels.
FRESH GARLIC
AGED GARLIC
PREPARATIONS
Total cholesterol
7% reduction
10-12% reduction
LDL cholesterol
4% reduction
15% reduction
HDL cholesterol no effect
10% increase
Systolic blood
5 mm Hg
1 1 mm Hg pressure reduction reduction
Diastolic blood no effect
5 mm Hg pressure reduction
Daily dosage
7. |
Phyllis A. Balch, CNC
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| Researchers noted the confirmation of the increased oxidative stress in smokers as compared with nonsmokers, and concluded that dietary supplementation with aged garlic may help to prevent diseases associated with oxidative stress like atherosclerosis. Garlic is available in capsule and liquid form for those who do not enjoy fresh garlic or worry about the socially unacceptable scent.
Garlic's sulfur compounds have the ability to reduce the formation of carcinogenic compounds, inhibiting the growth of different types of cancer, including colon cancer. |
Mark Blumenthal
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| AGE ™ (Kyolic®) aged garlic extract: 300-800 mg, 3 times daily or 1-5 ml daily (Steiner 2001; Steiner etal, 1996; Rahman and Billington, 2000; USP, 2002; Lau etal, 1987).
Duration of Administration
Long-term treatment is generally advised in the prevention of atherosclerosis (Koscielny et al., 1999), and the prophylaxis and treatment of peripheral arterial vascular diseases (ESCOP, 1997). Epidemiological observations support the long-term consistent use for prevention of cancer in the stomach and intestines (You et al, 1989). |
Phyllis A. Balch, CNC
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| Garlic also has antibacterial, antiviral, and antifungal properties. aged garlic extract provides the greatest concentration of beneficial compounds; however, fresh garlic and garlic oil can be used daily for favorable results. (More information about this powerful herb can be found in Chapter 20).
Ginkgo
Ginkgo biloba has a stabilizing effect on cellular membranes. It also has powerful antioxidant effects in the brain, retina, and cardiovascular system. |
Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson
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 Cardiovascular benefits are supported by the antithrombotic activity, which has been shown in several studies, and an antiplatelet effect demonstrated by aged garlic extracts in humans.
Other health benefits produced by garlic are antibacterial, antiviral and antifungal effects, and, more importantly, chemopreventative activity against carcinogenesis in various experimental models. Diallylsulphide is thought to inhibit carcinogen activation via cytochrome
Toxicology
Garlic has few side effects, apart from gastrointestinal effects at very high doses. |
Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine
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 When working with a sulfur compound for use against prostate cancer, researchers at Memorial Sloan-Kettering Cancer Center in New York found that aged garlic, referred to as S-allylmercaptocysteine (SAMC), improved the breakdown of testosterone significantly. The SAMC aged garlic extract slowed the cancer cell's growth by as much as 70 percent compared to untreated cells. This compound in garlic also cut the production of two proteins in the blood, including the prostate-specific antigen or PSA. The PSA test is the most widely used blood test for prostate cancer screening. |
Gary Null
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| Borek at Tufts University School of Medicine in his study on garlic concluded that "compelling evidence supports the beneficial health effects attributed to aged garlic extract (AGE), i.e., reducing the risk of . . . the oxi-dant-mediated brain cell damage that is implicated in Alzheimer's disease."34
Melatonin
Reiter and his colleagues defined the role of melatonin in antiaging as a multifaceted free radical scavenger and antioxidant. It detoxifies a variety of free radicals including the hydroxyl radical, peroxynitrite anion, singlet oxygen, and nitric oxide. |
C. P. Khare
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| For hyperlipidaemia, 600-900 mg of dried garlic powder or 10 g of raw garlic or 18 mg of garlic oil or aged garlic extract (dosage as per product literature) is being recommended; for patients suffering from atherosclerosis 600-1200 mg of dry garlic powder. A daily dose of 900 mg of garlic powder is indicated in fibrinolysis and platelet aggregation.
Hypoglycaemic effect of garlic has not yet been substantiated clinically, though both onion and garlic are given in natural form (50 g daily) for reducing the dose of insulin and for keeping diabetes under control. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
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| The data for aged garlic in the precedin; table are based on a recently completed double-blind study of forty-one men with beginning cholesterol levels in the 220- to 290-mg/dl range.28 The men received either aged garlic (7.2 grams per day!) or a placebo for six months and then were switched to the other supplement for an additional four months. The results demonstrated a reduction of total cholesterol of seven percent, and LDL cholesterol of four percent, but no changes in HDL cholesterol or triglyceride levels were noted. The systolic blood pressure dropped an average of 5. |
| These results were generally achieved within one to three months; significantly better results are achieved in a shorter amount of time with the fresh garlic preparations compared to aged garlic.
Blood pressure reductions have also been greater when using fresh garlic preparations than when using aged garlic. With fresh garlic preparations, typical reductions of 11 mm Hg for the systolic and 5.0 in the diastolic are usually achieved within a one- to three-month period. |
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